Trafficked Malayan pangolins contain viral pathogens of humans
Nature Microbiology(2022)
摘要
Pangolins are the most trafficked wild animal in the world according to the World Wildlife Fund. The discovery of SARS-CoV-2-related coronaviruses in Malayan pangolins has piqued interest in the viromes of these wild, scaly-skinned mammals. We sequenced the viromes of 161 pangolins that were smuggled into China and assembled 28 vertebrate-associated viruses, 21 of which have not been previously reported in vertebrates. We named 16 members of Hunnivirus , Pestivirus and Copiparvovirus pangolin-associated viruses. We report that the l -protein has been lost from all hunniviruses identified in pangolins. Sequences of four human-associated viruses were detected in pangolin viromes, including respiratory syncytial virus, Orthopneumovirus , Rotavirus A and Mammalian orthoreovirus . The genomic sequences of five mammal-associated and three tick-associated viruses were also present. Notably, a coronavirus related to HKU4-CoV, which was originally found in bats, was identified. The presence of these viruses in smuggled pangolins identifies these mammals as a potential source of emergent pathogenic viruses.
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关键词
Viral reservoirs,Virology,Life Sciences,general,Microbiology,Medical Microbiology,Parasitology,Infectious Diseases
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