Simultaneous quantification of urinary tobacco and marijuana metabolites using solid-supported liquid-liquid extraction coupled with liquid chromatography tandem mass spectrometry

Volha Yakimavets,Tian Qiu,Parinya Panuwet,Priya E D'Souza,Patricia A Brennan,Anne L Dunlop,P Barry Ryan,Dana Boyd Barr

Journal of Chromatography B（2022）

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摘要

•The developed method quantifies urinary OH-COT, COT, and COOH-THC simultaneously.•Solid-supported liquid-liquid extraction was used to extract human urine samples.•The 1st method for simultaneous measurement of tobacco and marijuana metabolites.•This method can be used to assess co-exposure to tobacco and marijuana products.

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关键词

Trans-3′-hydroxycotinine,Cotinine,11-nor-9-carboxy-delta 9-tetrahydrocannabinol,Supported liquid extraction,Tobacco metabolites,Marijuana metabolites

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