Co-amorphous systems using epigallocatechin-3-gallate as a co-former: Stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms

Jinfeng Chen,Huaning Li, Xiangwei Li,Dandan Yuan,Hongqing Cheng,Yixin Ke,Jianming Cheng,Zengwu Wang,Jing Chen,Junsong Li

European Journal of Pharmaceutics and Biopharmaceutics（2022）

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摘要

•EGCG as a co-former applied to co-amorphous systems (CAMs) was first reported.•Such CAMs showed good physical stability either under dry or 75% RH conditions.•The dissolution rate of such CAMs was improved significantly compared to model drugs.•The bioavailability of such CAMs has markedly increased in Cmax and AUC0-t compared to model drugs.•The molecular mechanisms of CAMs formation were miscibility, hydrogen bonds and π-π interactions.

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关键词

Co-amorphous systems,Epigallocatechin-3-gallate,Simvastatin,Nifedipine,Co-former,Stability,Non-sink dissolution,Pharmacokinetic,Molecular mechanisms

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