A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.

Fan Yang,Jezabel Rodriguez-Blanco,Jun Long,Marzena Swiderska-Syn,Daniel T Wynn,Bin Li,Chen Shen,Anmada Nayak,Yuguang Ban,Xiaodian Sun,Robert K Suter,Heather J McCrea,Anthony J Capobianco,Nagi G Ayad,David J Robbins

Molecular cancer research : MCR（2022）

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摘要

This work describes a novel, druggable UHRF1/DNMT1/GLI complex that regulates SHH-dependent tumor growth, and highlights an FDA-approved drug capable of disrupting this complex to attenuate tumor growth.

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