A straightforward strategy to spatially organize repulsive and attractive cues on Zwitterionic PEDOTs
Colloid and Interface Science Communications(2022)
摘要
Solving the conflict between the low impedance and biofunctionalization for the patterned conducting polymer biointerface/devices remains a challenge. Moreover, with our limited knowledge, the efforts to fabricate a patterned conducting polymer biointerface free from nonspecific protein/cell interaction are also missing. Herein, we developed a strategy to spatially organize cell-repulsive and attractive cues on an all-conducting-polymer biointerface by using two zwitterionic poly(3,4-ethylenedioxythiophene) (PEDOT) copolymers with opposite cell affinities. This dual-biofunction pattern of the PEDOT platform, mimicking the brain microenvironment for neural circuit assembly, organizes the cell-repulsive and specific cell-attractive cues spatially to regulate the cell attachment and differentiation. This platform also demonstrated a striking integration of low impedance and nonspecific protein/cell-binding resistance. We envision this approach, utilizing the diverse zwitterionic PEDOTs, would be attractive for bioelectronic applications, where a precise collection/delivery of electrical signals is necessary.
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关键词
Poly(3,4-ethylenedioxythiophene),Zwitterion,Phosphorylcholine,Cell patterning,Antifouling
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