Dynamic Refolding of OxyS sRNA by the Hfq RNA Chaperone

Huahuan Cai,Jorjethe Roca,Yu-Fen Zhao,Sarah A Woodson

Journal of Molecular Biology（2022）

引用 3|浏览3

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摘要

•Hfq RNA chaperone remodels small RNAs and mRNAs for post-transcriptional regulation.•Single molecule FRET reveals the kinetics of restructuring OxyS small RNA by Hfq.•Restructuring requires conserved arginines on the rim of the Hfq hexamer.•Intrinsically disordered regions slow down transitions between OxyS conformations.•Basic and disordered regions of Hfq work together to restructure RNA for regulation.

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关键词

RNA chaperone,Intrinsically disordered protein,Small RNA,Single molecule fluorescence microscopy,Sm protein

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