A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics.

Priya U Kumthekar,Michael J Avram,Andrew B Lassman,Nancy U Lin,Eudocia Lee,Sean A Grimm,Margaret Schwartz,Kirsten L Bell Burdett,Rimas V Lukas,Karan Dixit,Isabella Perron,Hui Zhang,William J Gradishar,Elena I Pentsova,Suriya Jeyapalan,Morris D Groves,Michelle Melisko,Jeffrey J Raizer

Neuro-oncology（2023）

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摘要

This study suggests promise for potentially improved outcomes of HER-positive LMD patients when treated with intrathecal trastuzumab while remaining safe and well-tolerated for patients.

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关键词

CNS metastases,HER2-positive metastases,leptomeningeal disease

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