Partial Identification of the Average Causal Effect in Multiple Study Populations: The Challenge of Combining Mendelian Randomization Studies.
Epidemiology (Cambridge, Mass.)(2023)
摘要
All pooled bounds computed in our application covered the null, illustrating how strongly point estimates from prior MR studies of this effect rely on within-study homogeneity assumptions. We discuss how the interpretation of both pooled bounds and point estimation in MR is complicated by possible heterogeneity of effects across populations.
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关键词
Instrumental variable,Mendelian randomization,Partial identification,Research synthesis
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