Upregulation of proto-oncogene ski by thyroid hormone in the intestine and tail during Xenopus metamorphosis

•Protooncogene Ski was upregulated by T3 in the tadpole intestine and tail.•Ski expression peaked at the climax of intestine and tail metamorphosis.•A TRE in exon 1 of the Ski gene could bind to TR/RXR heterodimer in vitro.•The TR/RXR-binding to SKI TRE could mediate promoter activation by T3 in vivo.•Ski was activated by T3 directly at the transcriptional level and might feedback to regulate TR activity during metamorphosis.