A novel ANN-CFD model for simulating flow in a vortex mixer

•A novel ANN-CFD based modelling methodology reported for simulating flow in a batch vortex mixer.•Two-phase flow problem requiring interface tracking simulations reduced to a single-phase flow problem.•ANN model trained with a large number of experimental data is used to predict vortex shape.•Validation of ANN-CFD model with the PIV data reported in literature.•Velocity profiles obtained from ANN-CFD model show good match with the profiles obtained from VOF simulations.•Validated ANN-CFD model used to have detailed insights into the flow and turbulence structures.