LUNG CARCINOID TUMORS: 10 YEARS OF EXPERIENCE

TYPE: Abstract TOPIC: Lung Cancer PURPOSE: Lung carcinoids (LC) account for 1-2% of all lung cancers. They are histologically classified in typical carcinoid (TC) and atypical carcinoid (AC), based on mitotic count and necrosis. The aim is to analyze clinical behavior and survival of patients treated with LC. METHODS: Retrospective study of all patients diagnosed with LC between 2011-2020 in our center. TC or AC classification was provided from surgical specimen, and non-specified (NS) tumor from biopsies, due to lack of representative sampling. RESULTS: We included 83 patients (59% female), mean age at diagnosis 62.2±13.3 years. 46 patients were asymptomatic, 26 presented with cough and dyspnea, 6 hemoptysis and 3 cushing syndrome. 45.8% had central pulmonary location, mostly a single lesion, with median greatest size 19±17mm. 48 cases were TC, 19 AC and 16 NS, with no statistical differences regarding to clinical and radiological data between TC and AC. Most patients (n=66; 79.5%) were diagnosed at stage I and II (8th edition TNM staging). The majority underwent surgery (n=59; 71.1%). 3 patients started somatostatin analogues for metastatic disease at diagnosis. Progression occurred in 7 cases associated with worse performance status (PS) and greater tumor size at diagnosis (p=0.035; p=0.006), with 4 related deaths. Mortality rate was 16.9%. The overall 5-year survival was 80% (89% in TC, 81% in AC; p=0.571). CONCLUSIONS: Most cases were incidentally diagnosed in early stages. LC have an indolent clinical behavior, favorable evolution and survival. CLINICAL IMPLICATIONS: LC progression is rare, possibly related with PS and greater tumor size at diagnosis. DISCLOSURE: Nothing to declare. KEYWORD: Lung carcinoid