Acute severe hepatitis of unknown origin in children: considerations from the perspective of immunology

Acute severe hepatitis of unknown origin in children,since it was firstly reported in Scotland on March 31,2022,has become an international concern with a high risk of acute liver failure requiring liver transplant.The typical causes for hepatitis have been ruled out and investigations revealed possible relationship between the disease and two potential pathogens,a special form of human adenovirus(HAdV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Acute hepatitis has been reported in children with multisystem inflammatory syndrome(MIS-C)and incorpo-rating insights from the immunology perspective is neces-sary to fully understand this disease.