Dual-responsive nanomotors for deep tumor penetration and subcellular arrangement

Chen-Guang Liu,Chao-Ping Fu,Yu-Hong Shi,Jun Zhong,Han-Xiao Tang,Jian-Ting Zhang,Ranjith Kumar Kankala,Shi-Bin Wang,Ai-Zheng Chen

Materials & Design（2022）

引用 5|浏览8

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摘要

•The novel rocket-like Janus-type CuS-ZIF-8-Dox JNPs were synthesized by a dual-solvent method.•The self-propelled CuS-ZIF-8-Dox JNPs penetrated deep tumor due to NIR-induced local thermal gradient.•Each component of CuS-ZIF-8-Dox JNPs showed specific optimal subcellular localization after cell internalization.

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关键词

Metal-organic frameworks,Janus nanomotor,Deep tumor penetration,Chemodynamic therapy,Photothermal therapy

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