Xueshuantong injection alleviates cerebral microcirculation disorder in middle cerebral artery occlusion/reperfusion rats by suppressing inflammation via JNK mediated JAK2/STAT3 and NF-κB signaling pathways

Gaorui Wang,Ziyu Chen, Yingying Song,Hui Wu,Ming Chen,Shusheng Lai,Xiaojun Wu

Journal of Ethnopharmacology（2022）

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摘要

MCAO/R promotes microvascular endothelial cell activation and release of inflammatory mediators such as IL-1β, IL-6, TNF-α, VCAM-1 and MMP-9, and induces cerebral microcirculation disorder in rats. XST injection improves cerebral microvescular structure damage and dysfunction in MCAO/R rats through inhibiting inflammation activated by JNK mediated JAK2/STAT3 and NF-κB signaling pathways.Image 1

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关键词

Xueshuantong injection,Panax notoginseng saponins,Cerebral microcirculation disorder,Middle cerebral artery occlusion/reperfusion,C-jun N-Terminal kinase,Nuclear factor kappa B

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