Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling (vol 7, pg 642, 2022)

K. Ozawa,M. Muller,O. Varlamov, M. W. Hagen,W. Packwood,T. K. Morgan,A. Xie,C. S. Lopez,D. Chung,J. Chen,J. A. Lopez,J. R. Lindner

JACC-BASIC TO TRANSLATIONAL SCIENCE（2023）

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摘要

•Excess vWF on the aortic valve surface predisposes to AS.•Valvular vWF likely promotes AS through myofibroblastic and osteogenic pathways known to be stimulated by platelet-derived factors.•Effects of excess endothelial vWF also cause arterial noncompliance, resulting in rapid progression of pressure-related ventricular remodeling.

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关键词

aortic valve stenosis,echocardiography,von Willebrand factor

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