Phenome-Wide Association Study of UMOD Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank

Elvis A Akwo,Hua-Chang Chen,Ge Liu,Jefferson L Triozzi,Ran Tao,Zhihong Yu,Cecilia P Chung,Ayush Giri,T Alp Ikizler,C Michael Stein,Edward D Siew,QiPing Feng,Cassianne Robinson-Cohen,Adriana M Hung

Kidney International Reports（2022）

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摘要

Robust associations were observed between variants linked with increased uromodulin expression and lower odds of UTIs and calculus and increased odds of CKD and hypertension. However, these associations varied significantly across ancestry groups and sex.

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关键词

genetic renal disease,hypertension,kidney stones,multiethnic,urinary tract infection,uromodulin

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