Correlations between sleep disturbance and brain structures associated with neurodegeneration in the National Alzheimer's Coordinating Center Uniform Data Set

•Sleep disturbance was associated with greater volumes in the lateral ventricles and greater total white matter hyperintensities.•Sleep disturbance was associated with lower mean volumes in 12 hippocampal, frontal, parietal, and temporal lobe regions.•Males, Hispanic participants, and those with less formal education were more likely to report sleep disruption.•A dementia diagnosis moderated the relationship between sleep disturbance and right and left lateral ventricular volumes.