Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway

Nesrine Ebrahim,Heba Elsayed Abd El-Halim,Omayma Kamel Helal,Nahla El-Eraky El-Azab,Omnia A.M. Badr,Amira Hassouna,Hajir A.Al Saihati,Nashwa Hassan Aborayah,Hanan Tawfeek Emam, Hend S. El-wakeel,Mohammad Aljasir,Mohamed El-Sherbiny, Naglaa A.S. Sarg,Gehan Ahmed Shaker,Ola Mostafa,Dina Sabry,Marwa Abdel Kader Fouly,Nicholas Robert Forsyth,Nehal M. Elsherbiny,Rabab F. Salim

Biomedicine & Pharmacotherapy（2022）

引用 6|浏览8

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摘要

Collectively, these data demonstrated that exosomes ameliorated diabetes-induced retinal injury via suppressing Wnt/ b-catenin signaling with subsequent reduction of oxidative stress, inflammation and angiogenesis.

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关键词

Anti-VEGF,BM-MSCs-Ex,DM,DR,Fz,GCL,GFAP,GSK3b,IHC,ILM,INL,IPL,LRP5/6,NFL,OLM,ONL,PRL,RPE,STZ,TNF-α

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