Confocal Raman Spectroscopy Assisted by Chemometric Tools: A Green Approach for Classification and Quantification of Octyl P-Methoxycinnamate in Oil-in-Water Microemulsions

•The proposed method does not use reagents and only 10 uL of sample are used.•Only 7 spectral variables were selected by SPA to build a LDA classification model.•PLS applied to Raman spectra allowed to quantify OMC and build distribution maps.•No separation techniques were used and no waste was generated in the analysis.•A greenery value of 0.85 was obtained for the method using the AGREE metric.