Effect of a nutritional support protocol on enteral nutrition and clinical outcomes of critically ill patients: a retrospective cohort study

Background: Enteral nutrition (EN) supply within 48 hours after intensive care unit (ICU) admission improves clinical outcomes. The & ldquo;new ICU evaluation & development of nutritional support protocol (NICE-NST)& rdquo; was introduced in an ICU of tertiary academic hospital. This study showed that early EN through protocolized nutritional support would supply more nutrition to improve clinical outcomes. Methods: This study screened 170 patients and 62 patients were finally enrolled; patients who were supplied nutrition without the protocol were classified as the control group (n=40), while those who were supplied according to the protocol were classified as the test group (n=22). Results: In the test group, EN started significantly earlier (3.7 +/- 0.4 days vs. 2.4 +/- 0.5 days, P=0.010). EN calorie (4.0 +/- 1.0 kcal/kg vs. 6.7 +/- 0.9 kcal/kg, P=0.006) and protein (0.17 +/- 0.04 g/kg vs. 0.32 +/- 0.04 g/kg, P=0.002) supplied were significantly higher in the test group. Although EN was supplied through continuous feeding in the test group, there was no difference in complications such as feeding hold due to excessive gastric residual volume or vomit, and hyper- or hypo-glycemia between the two groups. Hospital mortality was significantly lower in the group that started EN within 1.5 days (42.9% vs. 11.8%, P=0.018). The proportion of patients who started EN within 1.5 Conclusions: The NICE-NST may improve EN supply and mortality of critically ill patients without increasing complications.