Targeting the mTOR Pathway for the Prevention of ER-Negative Breast Cancer.

Abhijit Mazumdar,William M Tahaney,Jamal L Hill,Yun Zhang,Sumankalai Ramachandran,Jitesh Kawedia,Jing Qian,Alejandro Contreras,Michelle I Savage,Lana A Vornik,Shizuko Sei,Altaf Mohammed,Powel H Brown

Cancer prevention research (Philadelphia, Pa.)（2022）

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摘要

Our results show that everolimus delays mammary tumor formation in multiple mouse models, suggesting that mTOR inhibitors will be useful for the prevention of ER-negative and triple-negative breast cancer in humans. See related Spotlight, p. 787.

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关键词

mtor pathway,cancer,er-negative

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