Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms

Ellis Nelissen,Britt T J van Hagen,Elentina K Argyrousi,Nick P van Goethem,Pim R A Heckman,Dean Paes,Danielle A J Mulder-Jongen,Johannes G Ramaekers,Arjan Blokland,Harald H H W Schmidt,Jos Prickaerts

Neuroscience Letters（2022）

引用 2|浏览7

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摘要

•Subtle stimulation of sGC by riociguat is sufficient to enhance memory.•Vascular mechanisms may contribute to the memory enhancing effects of riociguat.•Targeting sGC is a potential novel approach for enhancing memory.•Low brain penetrance may limit clinical efficacy if the blood–brain barrier is intact.

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关键词

Cognition,Pharmacokinetics,Guanylyl cyclase,Spatial memory,Guanosine monophosphate

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