A crossover study evaluating the sex‐dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects

H. J. ( Hemme) Hijma, I. W. ( Ingrid) Koopmans, E. ( Erica) Klaassen,R. J. ( Robert Jan) Doll,R. G. J. A. ( Rob) Zuiker,G. J. ( Geert Jan) Groeneveld

British Journal of Clinical Pharmacology（2022）

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摘要

TSD induced sex-dependent hyperalgesia on cold, heat and pressure pain, and CPM response. These results suggest that the TSD model may be suitable to evaluate (novel) analgesics in early-phase drug studies.

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关键词

drug development,pain,randomized controlled trial

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