Portopulmonary Hypertension: The Interplay Between the Liver and Pulmonary Arteries

Portopulmonary hypertension (PPHTN) is a cause of pre-capillary pulmonary hypertension (PH) that occurs in the setting of advanced liver disease [1]. It highlights the close and dynamic relationship between the liver, right ventricle (RV), and pulmonary arteries (Figure 1). However, it is not as simple as the pressure transmission across a compliant, low-pressure right ventricle and associated remodelling. Peppas et al. [2] provide a comprehensive review of PPHTN, but also show that there are still significant gaps in our knowledge and clinical practice with regards to this type of PH.