The role of autophagy in high-fat diet-induced insulin resistance of adipose tissues in mice.

Yovita Permata Budi,Yi-Hsuan Li,Chien Huang,Mu-En Wang,Yi-Chun Lin,De-Shien Jong,Chih-Hsien Chiu,Yi-Fan Jiang

PeerJ（2022）

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摘要

Long-term high-fat diet promotes insulin resistance, late-stage autophagy inhibition, ER stress, and apoptosis in adipose tissue. Autophagy suppression may not affect insulin signaling transduction phosphatase expression but indirectly causes insulin resistance through ER stress or apoptosis.

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关键词

Apoptosis,Autophagy,ER stress,High-fat diet,Insulin resistance,Obesity

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