How splicing confers treatment resistance in prostate cancer.
eLife（2022）
摘要
A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
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关键词
AR-V7,androgen receptor,cancer biology,human,intranuclear mobility,nuclear import,prostate cancer,transcriptional activity
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