Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic-Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study.

Gwendal Coste,Céline Chabanne,Camille Tron,Bernard Lelong,Marie-Clémence Verdier,Mikael Roussel,François Le Gall,Bruno Turlin,Mireille Desille-Dugast,Erwan Flécher,Bruno Laviolle,Florian Lemaitre

Therapeutic drug monitoring（2023）

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摘要

In this cohort of well-immunosuppressed patients, no association was observed for any of the PK parameters, including C blood , with the occurrence of BPAR. However, a trend was noticed for the C EMB and C EMB/blood of cyclosporin A. Further studies in higher-risk patients may help optimize the use of C EMB and C PBMC for CNI TDM in HTR.

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tissular calcineurin inhibitors pharmacokinetic–pharmacodynamic,heart transplant recipients,pharmacokinetic–pharmacodynamic relationship

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