Nox5 expression in a vascular smooth muscle cell-specific manner induces fibroblast phenotypic switch and pro-fibrotic effects

Augusto Montezano,Francisco Rios,Zachariel Blaikie,Tomador Saad,Livia Camargo,Roberto Palacios-Ramirez,Antoine Tarjus,Agnieszka Sagan,Wendy Beattie,Tomasz Guzik,Frederic Jaisser,Delyth Graham,Rhian M. Touyz

Journal of hypertension（2022）

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摘要

Our findings suggest that Nox5 in VSMCs influences fibroblast phenotypic switching to myofibroblasts that likely influences cardiovascular and renal fibrosis in hypertension.

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关键词

fibroblast phenotypic switch,cell-specific,pro-fibrotic

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