Isothermal microcalorimetry versus checkerboard assay to evaluate in vitro synergism of meropenem-amikacin and meropenem-colistin combinations against multidrug-resistant Gram-negative pathogens

Alberto Antonelli,Marco Coppi,Chaitanya Tellapragada,Badrul Hasan,Ainhize Maruri,Desiree Gijón,Fabio Morecchiato,Corné de Vogel,Annelies Verbon,Willem van Wamel,Kasper Nørskov Kragh,Niels Frimodt-Møller,Rafael Cantón,Christian G Giske,Gian Maria Rossolini

International Journal of Antimicrobial Agents（2022）

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摘要

ITMC showed very good concordance with CKBM against a large collection of multi-drug-resistant Gram-negative clinical isolates, and could be implemented for the rapid evaluation of in-vitro activity of antimicrobial combinations.

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