Yeast β‐glucan Improves Insulin Sensitivity and Hepatic Lipid Metabolism in Mice Humanized with Obese Type 2 Diabetic Gut Microbiota

Kathleen A.J. Mitchelson,Tam T.T. Tran,Eugene T. Dillon,Klara Vlckova,Sabine M. Harrison,Alexandra Ntemiri,Katie Cunningham, Irene Gibson,Francis M. Finucane,Eibhlís M. O'Connor,Helen M. Roche,Paul W. O'Toole

Molecular Nutrition & Food Research（2022）

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摘要

Hepatic metabolism is adversely affected by OBD microbiome colonization with high-fat feeding, but partially resolved by yeast β-glucan. More targeted dietary interventions that encompass the interactions between diet, gut microbiota, and host metabolism may have greater treatment efficacy.

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关键词

gut microbiota,hepatic triacylglycerol (TAG),high-fat diet,type 2 diabetes,yeast β-glucan

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