Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.

Lili Xiao,Hong Cheng,Haiqing Cai,Yue Wei,Gaohui Zan,Xiuming Feng,Chaoqun Liu,Longman Li,Lulu Huang,Fei Wang,Xing Chen,Yunfeng Zou,Xiaobo Yang

Environmental health perspectives（2022）

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摘要

Our findings suggested that heavy metals contributed to higher prevalence of ADL disability and that locus-specific DNA methylation are partial mediators, providing potential biomarkers for further cellular mechanism studies. https://doi.org/10.1289/EHP10602.

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关键词

dna methylation,heavy metals,daily living disability,epigenome-wide

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