Investigation of prognostic biomarkers in patients with urothelial carcinoma treated with platinum-based regimens

Kyriaki Papadopoulou,Georgia-Angeliki Koliou,Dimitrios Tsimiliotis,Vassiliki Kotoula,Periklis Foukas,Anna Goussia,Marinos Tsiatas,Anastasios Visvikis,Kyriakos Chatzopoulos,Martha Nifora,Antonia Charchanti,Anna Koumarianou,Christos Christodoulou,Dimitrios Pectasides,Amanda Psyrri,Florentia Fostira,George Fountzilas,Epaminontas Samantas

Urologic Oncology: Seminars and Original Investigations（2022）

引用 1|浏览20

暂无评分

摘要

•DNA damage response and repair (DDR) alterations confer cisplatin sensitivity in muscle invasive bladder cancer (MIBC) patients.•Immune markers PD-L1, TILs or CD8+ are also potential biomarkers for cisplatin response in MIBC.•TP53, ARID1A, ERCC2 and BRCA2 were the top mutated genes among our study's tumors from 66 BC patients administered platinum regimens.•Immune markers positively correlated with each other and PD-L1 with the basal subtype.•DDR mutations, immune markers or subtypes were not associated with overall survival.

查看译文

关键词

Bladder cancer,DNA damage response and repair,Platinum sensitivity, PD-L1,Subtype

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要