Point mutation L116R in interferon‐regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells

Daniel Staudenraus, Alekhya Porapu,Hanna Leister,Dennis Das Gupta,Michael Lohoff

European Journal of Immunology（2022）

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摘要

IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4.

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关键词

IRF4,T-cell-differentiation,cytokine,interleukin,point mutation

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