Dopaminylation in Psychostimulant Use Disorder Protects Against Psychostimulant Seeking Behavior by Normalizing Nucleus Accumbens (NAc) Dopamine Expression.

Kenneth Blum,Mark S Gold,Jean L Cadet,David Baron,Abdalla Bowirrat,Panayotis K Thanos,Raymond Brewer,Rajendra D Badgaiyan,Marjorie C Gondré-Lewis

Current psychopharmacology（2022）

引用 5|浏览8

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摘要

The decrease in Src signaling in NAc D2-MSNs, (like the DRD2 Taq A2 allele, a well-known genetic mechanism protective against SUD) normalizes the NAc dopamine expression and decreases cocaine reward and motivation to self-administer cocaine. The Srcin1 may be an important therapeutic target.

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关键词

DRD2 gene,Src,cocaine,histone arginine (R) methylation,medium spiny neurons,p140CAP,psychostimulants

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