Early biomarkers predicting outcome in a porcine model of acetaminophen intoxication: A pilot study.

Christian Thiel, Ulrika Lischner,Matthias Morgalla,Andreas Peter,Martin Schenk,Alfred Königsrainer,Karolin Thiel

Advances in clinical and experimental medicine : official organ Wroclaw Medical University（2022）

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摘要

Tumor necrosis factor alpha, IL-6, lactate, prothrombin time, and albumin blood concentration were identified as early predictors of outcome after acetaminophen intoxication. An elevated TNF-α level before acetaminophen exposure was the earliest prognostic marker for a lethal outcome. Therefore, it could serve as a very early indicator of prognosis.

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关键词

acetaminophen intoxication,acute liver failure,cytokines,porcine model,prognostic markers

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