Mucin 1 aggravates synovitis and joint damage of rheumatoid arthritis by regulating inflammation and aggression of fibroblast-like synoviocytes.

Yaoyao Zou,Xuepei Zhang,Jinjian Liang,Liqin Peng,Jiale Qin, Feng Zhou,Ting Liu,Lie Dai

Bone & joint research（2022）

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摘要

Upregulated MUC1 promotes the aggression of rheumatoid synoviocytes via Rho guanosine triphosphatases (GTPases), thereby facilitating synovitis and joint destruction during the pathological process of RA.Cite this article: 2022;11(9):639-651.

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关键词

Cdc42,Fibroblast-like synoviocytes,Inflammation,Joint destruction,Mucin 1,RNAs,Rheumatoid arthritis,cytokines,fibroblast-like synoviocytes (FLSs),inflammation,joint damage,joint destruction,synoviocytes,synovitis

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