Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression.

Joseph M Rocco,Elizabeth Laidlaw,Frances Galindo,Megan Anderson,Adam Rupert,Jeanette Higgins,Ornella Sortino,Ana M Ortega-Villa,Virginia Sheikh,Gregg Roby,Safia Kuriakose,Andrea Lisco,Maura Manion,Irini Sereti

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

Severe mycobacterial IRIS and HLH have an overlapping pathogenesis involving IFNγ and unopposed T-cell activation causing severe inflammatory disease clinically distinguished by hyperferritinemia (hyperferritinemic IRIS [FIRIS]). Hemoglobin, ferritin, CXCL9, and sCD25 identify high-risk patients and may improve risk stratification and therapeutic strategies for mycobacterial IRIS.

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human immunodeficiency virus,immune reconstitution inflammatory syndrome,macrophage activation syndrome,mycobacteria,tuberculosis

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