Free radical-involved trifluoromethylthiolation cyclization of alkenes to access SCF3-substituted indolo[2,1-a]isoquinolines

Free radical-promoted tandem trifluoromethylthiolation of alkenes with AgSCF3, which provides an efficient protocol for the construction of SCF3-modified indolo[2,1-a]isoquinolines with moderate to good yields. A series of scaled-up experi-ments, other substrate transformations, and radical inhibition experiments were operated to verify the merit of this reaction system.