Evaluating group-sequential non-inferiority clinical trials following interim stopping: The HIV Prevention Trials Network 083 trial.

Brett S Hanscom,Deborah J Donnell,Thomas R Fleming,James P Hughes,Marybeth McCauley,Beatriz Grinsztejn,Raphael J Landovitz,Scott S Emerson

Clinical trials (London, England)（2022）

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摘要

For the HIV Prevention Trials Network 083 trial, the difference between corrected inferential statistics and naive results was quite small-as will often be the case-nevertheless, it is appropriate to report and publish the most accurate and unbiased statistical results.

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关键词

Group-sequential trials,HPTN 083,early stopping,non-inferiority

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