Quantitative Imaging of Non-Standard Radionuclides with Long Axial Field-of-View PET

Most clinical PET scans involve radiotracers labeled with 18 F. A number of radiotracers labeled with nuclides other than 18 F have been introduced, including 68 Ga-labeled PSMA, 68 Ga- and 64 Cu-DOTATATE, and 89 Zr-labeled antibodies or minibodies. These "non-standard" radionuclides have complex decay properties that are challenging for quantitative PET imaging (e.g., low signal due to low positron fraction and/or long half-life that limits injected activity, cascade gammas). The high sensitivity of a long axial field-of-view (AFOV) system can mitigate the low signal, but the wide axial angle coupled with the additional gammas can lead to more scatter and random events that pose a challenge for conventional corrections. In this work we imaged uniform cylindrical phantoms filled with non-standard radionuclides ( 52 Mn, 55 Co, 64 Cu, 68 Ga, 86 Y, 89 Zr) on the PennPET Explorer (112-cm AFOV) to assess quantitative accuracy and image uniformity in comparison to 18 F. Lowering the upper energy threshold (E max ) was studied to reduce contributions from higher energy gammas. Data were reconstructed using the time-of-flight list-mode ordered subsets expectation maximization algorithm with standard corrections for scatter and random coincidences. Uptake recovery was 5-10% of the true activity for radionuclides without prompt gammas, whereas inaccurate activity estimates and significant image non-uniformities were observed for 52 Mn, 55 Co and 86 Y. Lowering E max and adding a DC offset to the scatter estimate to compensate for the cascade gammas led to improved accuracy and uniformity, but further refinements of the corrections are needed. This work will pave the way for quantitative human studies with these non-standard radionuclides.