Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis

Xiangjie Chen,Qiuyu Wu,Xinhua Cao, Yunshan Yang,Zheng Gong,Tengfei Ren,Qian Du,Yukang Yuan,Yibo Zuo,Ying Miao,Jiuyi He,Caixia Qiao,Zhijin Zheng,Tingting Zhang,Yang Xu,Depei Wu,Qiao Wang,Lin Huang,Zhijun Xie,Haitao Lv

International Immunopharmacology（2022）

引用 2|浏览0

暂无评分

摘要

•IFN-I signaling was over-activated in the local knuckles of rheumatoid arthritis mice.•Menthone inhibited the activity of the IFN-I signaling pathway.•Menthone downregulated Tyk2 protein levels.•Menthone promoted polyubiquitination of Tyk2 protein.

查看译文

关键词

Menthone,Interferon,Tyk2,Ubiquitination,Rheumatoid arthritis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要