Use of a MAIT-Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination.

Owen Jensen,Shubhanshi Trivedi,Kelin Li,Jeffrey Aubé,J Scott Hale,Edward T Ryan,Daniel T Leung

Pathogens & immunity（2022）

引用 3|浏览11

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摘要

Using a murine model, we demonstrate the potential, as well as the limitations, of targeting MAIT cells to improve antibody responses to mucosal cholera vaccines. Our study highlights the need for future research optimizing MAIT-cell targeting for improving mucosal vaccines.

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关键词

5-OP-RU,Cholera,MAIT cells,cholera vaccines,conjugate vaccine,mucosal adjuvant

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