Effects of teriparatide and loading modality on modeling-based and remodeling-based bone formation in the human femoral neck

•Teriparatide (TPTD) mainly increases remodeling-based formation (RBF) early.•Patient age and body weight influence the efficacy of TPTD treatment.•TPTD increases RBF when body weight is lower, modeling-based formation when higher.•Femoral neck geometry alters TPTD effects differently under tension vs. compression.