A convenient synthesis of ellagic acid from methyl gallate and SARS-CoV-2 3CLpro antiviral activity

M. Dolors Pujol,Salha Hamri,Olga Abian,Miquel Viñas,Daniel Jahani,Jaume Ginard, Francesc Navarro, Rosa Reches, Josep Vilardell

Synthesis（2022）

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摘要

A practical synthesis of ellagic acid has been achieved from methyl gallate ester by a proposed synthetic route of five steps, ketal protection, regioselective bromination, bis-lactonization, C-C bond formation between the aromatic rings of galloyl groups, and ketal-deprotection in 38% overall yield. Ellagic acid showed a slight inhibitory activity on the SARS-CoV-2 eCLpro protease.

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关键词

ellagic acid,gallic acid,polyphenols,reductive coupling,ketals

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