MRGPRX2 in drug allergy: What we know and what we do not know.

Pavel Kolkhir,Hydar Ali,Magda Babina,Didier Ebo,Vito Sabato,Jessy Elst,Stefan Frischbutter,Polina Pyatilova,Marcus Maurer

The Journal of allergy and clinical immunology（2022）

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摘要

Immediate drug hypersensitivity reactions are characterized by a broad spectrum of symptoms, varying from urticaria, angioedema, pruritus, upper and lower respiratory symptoms, gastrointestinal symptoms, and hypotension to anaphylaxis. Mechanistically, these reactions often involve mast cell (MC) degranulation, as reflected by elevated serum tryptase levels.1,2

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