TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients.

Luís Alberto de Pádua Covas Lage,Guilherme Carneiro Barreto,Hebert Fabricio Culler, Jéssica Billar Cavalcante,Lucas Bassolli de Oliveira Alves,Luciana Nardinelli,Israel Bendit,Maria Cláudia Nogueira Zerbini,Vanderson Rocha,Juliana Pereira

Cancer biomarkers : section A of Disease markers（2022）

引用 3|浏览11

暂无评分

摘要

Mutations in RHOA, TET-2 and DNMT3A were frequent in Brazilian patients with nPTCL. TET-2 mutations were associated with lower ORR for CHOP-like chemotherapy, decreased PFS and unfavorable clinical-biological characteristics in non-ALCL (PTCL, NOS and AITL). Further studies using a larger cohort may validate our findings.

查看译文

关键词

Nodal peripheral T-cell lymphomas,biomarkers,epigenetics,mutation,prognosis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要