An observational retrospective study on microsatellite instability (MSI) in metastatic melanoma

Microsatellite instability (MSI) has been reported in skin melanoma and is thought to be a progression dependent phenomenon seen predominantly on metastases. However, a paucity of data is available about frequency, predictive and prognostic value of MSI in melanoma, in particular using the pentaplex panel of markers approved for colon cancer. Primary aim of this study was to provide a descriptive analysis of the presence of MSI in distant melanoma metastases, regardless of BRAF status and type of first-line treatment.