Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma

Qian Long,Chunyu Huang,Jinsheng Huang,Qi Meng, Yanjun Cheng,Yilin Li,Liru He,Miao Chen,Changlin Zhang,Xiaonan Wang,Wancui Zhu,Jin Peng,Dingbo Shi,Fufu Zheng,Pei Dong,Wuguo Deng

Journal of Advanced Research（2022）

引用 1|浏览10

暂无评分

摘要

•JAK3 promoter methylation was correlated with JAK3 expression in ccRCC.•JAK3 promoter methylation was associated with clinicopathological characteristics in ccRCC.•JAK3 promoter methylation was associated with overall survival in ccRCC.•JAK3 promoter methylation was correlated with immune cell infiltration in ccRCC.•JAK3 promoter methylation was correlated with the expression of immune checkpoint molecules in ccRCC.•JAK3 promoter methylation was a potential biomarker for predicting responses to immune checkpoint inhibitors in ccRCC.

查看译文

关键词

Janus kinase 3,Renal cell carcinoma,Epigenetic biomarker,Tumor immune microenvironment,Tumor immune cell infiltration

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要