Genetic variants associated with ALT elevation from therapeutic acetaminophen.

Andrew A Monte,Ian Arriaga Mackenzie,Jack Pattee,Sasha Kaiser, Emileigh Willems,Barry Rumack,Kate M Reynolds,Richard C Dart,Kennon J Heard

Clinical toxicology (Philadelphia, Pa.)（2022）

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摘要

Acetaminophen induced ALT elevation at therapeutic doses was not associated with variation in most genes associated with acetaminophen metabolism or immune-induced DILI in this cohort. The role of polymorphism in acetaminophen-induced elevated ALT needs further examination.

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关键词

Acetaminophen,drug induced liver injury,genetic,hepatotoxicity,pharmacogenetics,therapeutic dose

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