X-linked hypophosphatemia: not only a skeletal disease but also a chronic inflammatory state

Meaux Marie-Noelle,Candide Alioli,Agnes Linglart,San-Drine Lemoine,Emmanuelle Vignot,Aurelia Berholet-Thomas,Olivier Peyruchaud,Sacha Flammier,Irma Machuca-Gayet,Justine Bacchetta

The Journal of clinical endocrinology and metabolism（2023）

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摘要

We describe for the first time a peculiar inflammatory profile in XLH. Since XLH patients have a propensity to develop arterial hypertension, obesity, and enthesopathies, and because inflammation can worsen these clinical outcomes, we hypothesize that inflammation may play a critical role in these extraskeletal complications of XLH.

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X-linked hypophosphatemia,inflammation,obesity,osteoclastogenesis,vitamin D

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